Biochemical and autoradiographic studies of different RNA's: evidence that transfer RNA is chromosomal in origin.
نویسندگان
چکیده
20 Urnes, P. J., cited in ref. 21. 21 Harrison, S. C., and E. R. Blout, J. Biol. Chem., 240, 299 (1965). 22 Simmons, N. S., C. Cohen, A. G. Szent-Gyorgyi, D. B. Wetlaufer, and E. R. Blout, J. Am. Chem. Soc., 83, 4766 (1961). 23Hazelwood, R. N., J. Am. Chem. Soc., 80, 2152 (1958). 24 Scanu, A., Circulation, 32, Suppl. 2, 30 (1965). 25 Blout, E. R., in Optical Rotatory Dispersion, ed. C. Djerassi (New York, N. Y.: McGrawHill Book Co., 1960), p. 263. 26 Blout, E. R., I. Schmier, and N. S. Simmons, J. Am. Chem. Soc., 83, 4766 (1961). 27 Yang, J. T., and T. Samejima, J. Biol. Chem., 238, 3262 (1963).
منابع مشابه
The Cellular Sites of Synthesis of Ribosomal and 4s Rna.
In previous publications,'-4 we presented evidence which indicates that the major portion of cytoplasmic RNA (C-RNA) is derived from RNA which is synthesized in the nucleolar region of the nucleus (n-RNA). Furthermore, it was proposed that n-RNA and the RNA of the extranucleolar parts of the nucleus (N-RNA) are synthesized independently of each other. These studies, carried out on the level of ...
متن کاملChemical etiology of nucleic acid structure.
Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.
متن کاملThe Base Composition of Nucleic Acids in Chromosomes, Puffs, Nucleoli, and Cytoplasm of Chironomus Salivary Gland Cells
The base composition of RNA from individually isolated giant chromosomes, puffed chromosome segments, nucleoli, and samples of cytoplasm from Chironomus salivary gland cells was determined by microelectrophoresis. Data on the adenine: guanine quotient of the chromosomal DNA were also obtained. The results show that: 1) Chromosomal, nucleolar, and cytoplasmic RNA's differ significantly from each...
متن کاملThe Differential Capacity for Rna Synthesis among Chromosomes: a Cytological Approach.
It is an established concept that in any given cell or tissue of a multicellular organism, only a part of the total genetic information is used. Although the exact mechanism has not been elucidated, it is presumed that reversible and irreversible inactivations of genetic loci with respect to RNA synthesis are the controlling factors. Hoyer and McCarthy' have demonstrated with DNA/RNA hybridizat...
متن کاملI-44: Mutagenesis during Embryogenesis
We developed several novel tools to genome wide screen for CNVs and SNPs in single cells. When applied to cleavage stage embryos from young fertile couples we discovered, unexpectedly, an extremely high incidence of chromosomal instability, a hallmark of tumorigenesis (Vanneste et al., Nature Medicine, 2009; Vanneste et al., Hum.Reprod., 2011). Not only mosaicisms for whole chromosome aneuploid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 54 6 شماره
صفحات -
تاریخ انتشار 1965