Human T-cell Leukemia Virus Type 2 produces a spliced antisense transcript encoding a protein that lacks a classical bZIP domain but still inhibits Tax2-mediated transcription Short title: HTLV-2 antisense transcript
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Section: Immunobiology Human T-cell Leukemia Virus Type 2 produces a spliced antisense transcript encoding a protein that lacks a classical bZIP domain but still inhibits Tax2-mediated transcription Short title: HTLV-2 antisense transcript Marilène Halin, Estelle Douceron 6, 7, , Isabelle Clerc, Chloé Journo 6, 7, , Nga Ling Ko, Sébastien Landry, Edward L. Murphy, Antoine Gessain, Isabelle Lemasson, Jean-Michel Mesnard, Benoît Barbeau, Renaud Mahieux 6, 7, 8†¶ 1: Département des Sciences Biologiques et Centre de recherche BioMed, Université du Québec à Montréal, 2080 Saint-Urbain Montréal, Québec, Canada H2X 3X8. 2: Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Département de Virologie, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France. 3: Centre d’études d’agents Pathogènes et Biotechnologies pour la Santé (CPBS), CNRS/UM1/UM2 UMR 5236, Montpellier, France 4: University of California, San Francisco, and Blood Systems Research Institute, San Francisco, USA. 5: Dept. of Microbiology and Immunology, Brody School of Medicine, East Carolina University, 600 Moye Blvd., Greenville, USA 6: Equipe Oncogenèse Rétrovirale, INSERM-U758 Virologie Humaine, 69364 Lyon Cedex 07, France 7: Ecole Normale Supérieure de Lyon, 69364 Lyon Cedex 07, France 8: IFR 128 Biosciences Lyon-Gerland, 69364 Lyon Cedex 07, France * and † These authors contributed equally Blood First Edition Paper, prepublished online July 14, 2009; DOI 10.1182/blood-2008-09-179879
منابع مشابه
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription.
Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) retroviruses infect T lymphocytes. The minus strand of the HTLV-1 genome encodes HBZ, a protein that could play a role in the development of leukemia in infected patients. Herein, we demonstrate that the complementary strand of the HTLV-2 genome also encodes a protein that we named APH-2 for "antisense protein of HTLV-2." APH-2 mRN...
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Retroviral gene expression generally depends on a full-length transcript that initiates in the 5' long terminal repeat (LTR), which is either unspliced or alternatively spliced. We and others have demonstrated the existence of an antisense transcript initiating in the 3' LTR of the Human T-cell Leukemia Virus type 1 (HTLV-1) that is involved in the production of HBZ (HTLV-1 basic leucine zipper...
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UNLABELLED Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) are highly related retroviruses that transform T cells in vitro but have distinct pathological outcomes in vivo. HTLV-1 encodes a protein from the antisense strand of its proviral genome, the HTLV-1 basic leucine zipper factor (HBZ), which inhibits Tax-1-mediated viral transcription and promotes cell proliferation, a hig...
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Human T-cell leukemia virus types 3 and 4 (HTLV-3 and HTLV-4) are recently isolated retroviruses. We have previously characterized HTLV-3- and HTLV-4-encoded antisense genes, termed APH-3 and APH-4, respectively, which, in contrast to HBZ, the HTLV-1 homologue, do not contain a typical bZIP domain (M. Larocque É Halin, S. Landry, S. J. Marriott, W. M. Switzer, and B. Barbeau, J. Virol. 85:12673...
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