Vessel Size Index and Blood Volume Imaging in Pancreatic Cancer Xenograft Model Using Ferumoxide
نویسندگان
چکیده
Introduction. Ferumoxtran is a superparamagnetic iron oxide (SPIO) MRI contrast agent that has been used to estimate blood volume fraction (BV) and the vessel size index (VSI, or average blood vessel diameter) [1] in tumours. The administration of SPIO in blood produces steady-state susceptibility contrast which can be related to BV (proportional to ΔR2* due to contrast injection) and VSI (proportional to D (ΔR2*/ ΔR2) 3/2 ) The technique assumes that the SPIO contrast agent remains intrasvascular, which may not be the case in leaky tumours. Ferumoxide (Feridex, Bayer Healthcare) is a SPIO agent which may be an attractive alternative, due to its clinical availability (ferumoxtran is no longer commercially available), and its larger particle size which may improve sequestration in the tumour vasculature (120-180 nm vs. 15-30 nm diameter for ferumoxide and ferumoxtran, respectively [2]). This work describes the use of ferumoxide in measuring BV and VSI in an orthotopic xenograft mouse model of pancreatic cancer.
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