The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism.

Molecular and Cellular Pathobiology The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism

Although considerable progress has been made toward understanding glioblastoma biology through largescale genetic and protein expression analyses, little is known about the underlying metabolic alterations promoting their aggressive phenotype. We conducted global metabolomic profiling on patient-derived glioma specimens and identified specific metabolic programs differentiating lowand high-grad...

TITLE: The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism AUTHORS:

Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ABSTRACT Although considerable progress has been made towards understanding glioblastoma biology through large-scale genetic and protein expression analyses, little is known about the underlyin...

The Metabolomic Signature of Malignant Glioma Reflects Accelerated

A prospective study of serum metabolites and glioma risk

Malignant glioma is one of the most lethal adult cancers, yet its etiology remains largely unknown. We conducted a prospective serum metabolomic analysis of glioma based on 64 cases and 64 matched controls selected from Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Median time from collection of baseline fasting serum to diagnosis was nine years (inter-decile range 3-20 years)...

Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based “starvation” strategies in BRCA1 carriers

We hypothesized that women inheriting one germline mutation of the BRCA1 gene ("one-hit") undergo cell-type-specific metabolic reprogramming that supports the high biosynthetic requirements of breast epithelial cells to progress to a fully malignant phenotype. Targeted metabolomic analysis was performed in isogenic pairs of nontumorigenic human breast epithelial cells in which the knock-in of 1...