Reply to ‘“Mycobacterium indicus pranii” Is a Strain of Mycobacterium intracellulare’: “M. indicus pranii” Is a Distinct Strain, Not Derived from M. intracellulare, and Is an Organism at an Evolutionary Transition Point between a Fast Grower and Slow Grower
نویسندگان
چکیده
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdoma; Kusuma School of Biological Sciences, Indian Institute of Technology, Hauz Khas, New Delhi, Indiab; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Indiac; National Institute of Pathology, Safdarjung Hospital, New Delhi, Indiad; Department of Biochemistry, University of Delhi South Campus, New Delhi, Indiae; Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad, Indiaf
منابع مشابه
“Mycobacterium indicus pranii” Is a Strain of Mycobacterium intracellulare
In the recent publication “Comparative Analyses of Nonpathogenic, Opportunistic, and Totally Pathogenic Mycobacteria Reveal Genomic and Biochemical Variabilities and Highlight the Survival Attributes of Mycobacterium tuberculosis,” Rahman et al. (1) used bioinformatic methods to examine the evolutionary relatedness and metabolic capacity of mycobacteria of diverse pathogenic potential. A key co...
متن کاملComparative Analyses of Nonpathogenic, Opportunistic, and Totally Pathogenic Mycobacteria Reveal Genomic and Biochemical Variabilities and Highlight the Survival Attributes of Mycobacterium tuberculosis
UNLABELLED Mycobacterial evolution involves various processes, such as genome reduction, gene cooption, and critical gene acquisition. Our comparative genome size analysis of 44 mycobacterial genomes revealed that the nonpathogenic (NP) genomes were bigger than those of opportunistic (OP) or totally pathogenic (TP) mycobacteria, with the TP genomes being smaller yet variable in size--their geno...
متن کاملMolecular analysis of clinical isolates previously diagnosed as Mycobacterium intracellulare reveals incidental findings of “Mycobacterium indicus pranii” genotypes in human lung infection
BACKGROUND Mycobacterium intracellulare is a major cause of Mycobacterium avium complex lung disease in many countries. Molecular studies have revealed several new Mycobacteria species that are closely related to M. intracellulare. The aim of this study was to re-identify and characterize clinical isolates from patients previously diagnosed with M. intracellulare lung disease at the molecular l...
متن کاملPolyphasic Taxonomic Analysis Establishes Mycobacterium indicus pranii as a Distinct Species
BACKGROUND Mycobacterium indicus pranii (MIP), popularly known as Mw, is a cultivable, non-pathogenic organism, which, based on its growth and metabolic properties, is classified in Runyon Group IV along with M. fortuitum, M. smegmatis and M. vaccae. The novelty of this bacterium was accredited to its immunological ability to undergo antigen driven blast transformation of leukocytes and delayed...
متن کاملMassive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution
Understanding the evolutionary and genomic mechanisms responsible for turning the soil-derived saprophytic mycobacteria into lethal intracellular pathogens is a critical step towards the development of strategies for the control of mycobacterial diseases. In this context, Mycobacterium indicus pranii (MIP) is of specific interest because of its unique immunological and evolutionary significance...
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