Controlled Release Behaviour of Nifedipine from the Pellets of Gelucire/Microcrystalline Cellulose Blends

The aim of the present study was to prepare matrix pellets loaded nifedipine (NF) as model drug by pellitization technique by using blend of gelucire 50/13 (GL) and glyceryl palmito stearate (GPS) as hydrophilic and hydrophobic carriers in different concentrations. This system was able to prolong the drug release, minimizing the drug related adverse effects and improve bioavailability in different GI-tract conditions. The prepared formulations was subjected to micromeritic properties, SEM, DSC, FTIR and stability studies. The obtained microspheres having smooth surfaces, with free flowing and good packing properties, angle of repose, % Carr’s index and tapped density values were within the limit. The drug loaded in microspheres was stable and compatible, as confirmed by DSC and FTIR studies. In-vitro drug release profile of NF from pellets was studied in simulated gastric fluid pH1.2 for initial 2h and in simulated gastric fluid pH 7.4 upto 22 h and compared with oral formulation Adalat CR 20 capsule. The release of drug from the pellets showed negligible drug release in pH1.2. Under intestinal conditions resulting optimum level of drug released in a controlled manner and exhibited fickian diffusion.