Difference in Adrenergic and Beta Receptors between Epididymal Ends of Dog Vas

KONDO, S., KAGAYA, M., TASHIMA, Y. and MORITA, T. The Quantitative Difference in Adrenergic Alpha-1, Alpha-2 and Beta Receptors between the Prostatic and Epididymal Ends of Dog Vas Deferens. Tohoku J. Exp. Med., 1992, 167 (2), 167-169 In order to study the regional differences in the distribution of adrenergic receptors of the vas deferens, we measured the amounts of adrenergic a-1, a-2 and R receptors in prostatic, intermediate, and epididymal portions of the dog vas deferens using radioligand binding techniques. Saturation experiments with 3H-prazosin, 3H-yohimbine, and 3H-dihydroxyalprenolol demonstrated that there were significant amounts of adrenergic a-1, a-2, and R receptors, respectively, in these three portions. a-1 receptors existed most densely in the whole vas deferens. The prostatic portion was found to have the largest amounts of a-1 and a-2 receptors among three portions studied. fl-Receptors were distributed most densely in the intermediate portion. a-1, a-2, and fi adrenergic receptors show different distribution patterns throughout the whole length of vas deferens. a-1 recoptor ; a-2 receptor ; fl-receptor; dog vas deferens