Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages.

نویسندگان

  • P A Denoel
  • R M Crawford
  • M S Zygmunt
  • A Tibor
  • V E Weynants
  • F Godfroid
  • D L Hoover
  • J J Letesson
چکیده

A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M was generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were similar to those of its parental strain in human monocyte-derived macrophages (MDM). These results suggest that BFR is not essential for the intracellular survival of B. melitensis in human MDM.

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عنوان ژورنال:
  • Infection and immunity

دوره 65 10  شماره 

صفحات  -

تاریخ انتشار 1997