Individualizing the intravitreal anti-VEGF dosing regimen for long-term management of neovascular AMD.

While anti-vascular endothelial growth factor (VEGF) therapy affords patients with neovascular age-related macular degeneration (AMD) a dramatically improved prognosis compared to all prior treatments, the chronic nature of the disease and the uncertainties regarding long-term dosing strategies represent important therapeutic challenges. Large randomized trials established the efficacy and safety of ranibizumab, bevacizumab, and aflibercept for the treatment of neovascular AMD, yet these studies offered little insight into the optimal dosing regimen for individual patients or how to manage patients after 2 years of intensive therapy. Unfortunately, the data regarding long-term outcomes for anti-VEGF therapy suggest that deviations from close monitoring and/or injections, even after 2 years, will likely result in an accelerated rate of vision loss in many eyes.1 Individualizing the intravitreal anti-VEGF dosing regimen for long-term management of neovascular AMD