R 1 Title : Genetic variation in the SLC 8 A 1 calcium signaling pathway is associated with susceptibility to Kawasaki disease and coronary artery abnormalities
نویسندگان
چکیده
Chisato Shimizu, MD*, Hariklia Eleftherohorinou, PhD, Victoria J. Wright, PhD, Jihoon Kim, MS, Martin P. Alphonse, MSc, James C. Perry, MD, Rolando Cimaz, MD, PhD, David Burgner, MD, PhD, Nagib Dahdah, MD, Long T. Hoang, PhD, Chiea Chuen Khor, PhD, Andrea Salgado, MD, Adriana H. Tremoulet, MD, MAS, Sonia Davila, PhD, Taco W Kuijpers, MD, Martin L. Hibberd, PhD, Todd A. Johnson, PhD, Atsushi Takahashi, PhD , Tatsuhiko Tsunoda, PhD, Michiaki Kubo, MD, PhD, Toshihiro Tanaka, MD, PhD, Yoshihiro Onouchi, MD, PhD, Rae S. M. Yeung, MD, PhD, Lachlan J. M. Coin, PhD , Michael Levin, FRCPCH, PhD , Jane C. Burns, MD on behalf of International Kawasaki Disease Genetics Consortium
منابع مشابه
Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities.
BACKGROUND Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkage studies only partially explain the influence of genetics on KD susceptibility. METHODS AND RESULTS To search for additional functional genetic variation, w...
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Background Kawasaki disease (KD) also known as mucocutaneous lymph node syndrome is the febrile and self-limited vasculitis that occurs in children of all ages, especially younger than five years of age. Here, we describe a case of Kawasaki disease with coronary artery aneurysm and a big clot in LV with a diameter of 1.5 cm. <stron...
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Genome-Wide Association Studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (CAD). F7 gene because of its role in activating the ...
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Background: Kawasaki disease (KD) is an acute vasculitis in children. Eosinophilia, a reflection of the host's immune response that can cause tissue damage, has been associated with KD, with eosinophils preferentially accumulating in the microvasculature. In early-stage Kawasaki disease (KD), lesions (perivasculitis and vasculitis) first form in the microvessels, which can then extend to the la...
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Background Kawasaki Disease (KD) is a vasculitis with multi-organ involvementof unknown etiology; it is the most common cause of pediatric-heart diseases in developed countries. Treatment with Intravenous Immunoglobulin (IVIG) prevents coronary artery lesions; although there are some IVIG-resistant cases, combination therapy with corticosteroids and IVIG is one of the recommendations for treatm...
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