Biocoordination, Computational Modeling and Antibacterial Sensitivities of Cobalt (ii), Nickel (ii), Copper (ii) and Bismuth (v) with Gentamicin and Amoxicillin Antibiotics Mixed Ligands

A new ligand was made by coupling gentamicin and amoxicillin. It is proposed that these effects result from complex formation of ligand with Co (II), Ni (II), Cu (II) and Bi (V). Metal coordination to novel ligand was studied by various spectroscopic techniques. The crystal system, lattice parameters, unit cell, particle size and volume were determined by XRPD. The crystallographic data of complex (1) are: triclinic, space group P1, a(Å) =15.621, b(Å) =14.119, c (Å) =23.491, V(Å ) =1112.00, α = 48.183, β о =37.56,γ о = 30.72 and for complex (4): crystal system, Triclinic, space group, P-1, a (Å) =8.290549, b(Å) =9.619387, c(Å) =16.12853, α = 63.75208, β =53.3017, γ =62.28692,V(Å } =1611.49. The molecular structures of the complexes were optimized by and calculations which indicated a square planar arrangement of ligand around the Co(II) ions.