Severe periorbital edema secondary to imatinib mesylate for chronic myelogenous leukemia.
نویسندگان
چکیده
A 70-year-old man developed severe periorbital edema secondary to imatinib mesylate (Gleevec; Novartis Pharmaceuticals Corp, East Hanover, NJ). Imatinib mesylate is a tyrosine kinase inhibitor with a high degree of specificity for the BCRABL, KIT, and platelet-derived growth factor receptor tyrosine kinases. It is thought that inhibition of platelet-derived growth factor receptor results in disruption of fluid homeostasis in the eyelids, resulting in the development of periorbital edema.
منابع مشابه
Periorbital edema secondary to imatinib mesylate
Imatinib mesylate (Gleevec((R))) is a well-established pharmacologic treatment for all phases of chronic myeloid leukemia and for advanced gastrointestinal stromal tumors (GISTs). Edema-related side effects are relatively common in imatinib therapy with the periocular skin representing one of the most common sites for localized edema. While the adverse effect of periorbital edema with imatinib ...
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ورودعنوان ژورنال:
- Archives of ophthalmology
دوره 125 7 شماره
صفحات -
تاریخ انتشار 2007