Split dosing for bowel preparation.

DKR Thus far, I am aware of 12 trials that have directly compared split dosing with evening-before dosing for bowel preparation, and all but 1 of these trials found that split dosing was superior with regard to efficacy. None of the trials found evening-before dosing to be superior. In these studies, the benefits of split dosing were particularly evident in the ascending, or right, colon. The magnitude of the effect of split dosing was quite impressive; in some of these studies, the number of patients who had an excellent or adequate preparation increased by 30–40% with split dosing, compared to evening-before dosing of the same preparation. Differences of this magnitude have not been seen when comparing different bowel preparations. Thus, splitting a bowel preparation is a more effective way of attaining an excellent or adequate bowel preparation than switching to a different preparation.