Effects of captopril, an angiotensin converting enzyme inhibitor on TAME-esterase induced contractions in rat aorta strips in vitro
نویسنده
چکیده
The in-vitro effects of Captopril an angiotensin converting enzyme inhibitor were studied on TAME-esterase, a component of the Kinin-Kallikrein system, induced contractions on rat aorta strips. Our results showed that contractile responses induced by TAME (EC50 6 x 10 M) were significantly attenuated when the aorta strips were pre-incubated with 1M Captopril (EC50 1.8 x10M). Based on our data we concluded that TAME-esterase induced contractions involve degradation of kinins by kinases.
منابع مشابه
Effect of genistein, a tyrosine kinase inhibitor, on TAME-esterase induced contractions in rat aorta in vitro.
Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution ...
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