Layering an API onto tablets using a perforated-drum coater: A case study

Controlling weight gain is an important factor when applying any coating, but it becomes absolutely critical when the coating contains an API. This article presents a case study that identifies the critical process parameters for developing a consistent and robust coating process that provides in-range results. low-dose drug products, although manufacturing highdose products is simpler because content uniformity across the batch is less of an issue. In the case of low-dose products, process optimization becomes critical to ensure quality and consistency. The two major factors are machine design and controlling the process parameters that most influence the quality of the finished product.