A new antifungal antibiotic, trichostatin.
نویسندگان
چکیده
A new antibiotic, trichostatin, was isolated from the metabolites of strains of Streptomyces hygroscopicus. It is active against trichophytons and some fungi. The structure was determined to be a derivative of a primary hydroxamic acid by chemical and spectroscopic evidences.
منابع مشابه
Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species.
OBJECTIVES Invasive mould infections are associated with a high mortality rate and the emergence of MDR moulds is of particular concern. Calcineurin and its chaperone, the heat shock protein 90 (Hsp90), represent an important pathway for fungal virulence that can be targeted at different levels. We investigated the antifungal activity of compounds directly or indirectly targeting the Hsp90-calc...
متن کاملبررسی فعالیت ضد قارچی اکتینومیست‌های جداشده از رسوبات بستر دریای مازندران
Background and purpose: Actinomycetes were always considered as a source of essential new antibiotic producers and secondary metabolite in pharmaceutical industries. This study aimed to isolate antibiotic producing actinomycetes from sediments of the Caspian Sea and investigate their potential as antifungal metabolites production. Materials and methods: Sediments of the Caspian Sea were collec...
متن کاملTaxonomic studies on Kitasatosporia cystarginea sp. nov., which produces a new antifungal antibiotic cystargin.
Taxonomic studies on a new species, Kitasatosporia cystarginea are presented. Among the several species already described in this genus, this strain is characteristic in forming distinct spirals of spore chains. A significant properties of the species is the production of a new antifungal antibiotic, cystargin.
متن کاملXanthoepocin, a new antibiotic from Penicillium simplicissimum IFO5762.
A new antifungal antibiotic xanthoepocin was isolated from the culture broth of Penicillium simplicissimum IFO5762. Xanthoepocin was obtained from the culture fluid by solvent extraction and chromatographic purification. It showed antibiotic activity against Gram-positive bacteria and yeasts.
متن کاملHistidinomycin, a new antifungal antibiotic.
A new antifungal antibiotic named histidinomycin was isolated from the broth filtrate of a streptomycete, tentatively designated as isolate H 878-MY 1. Histidinomycin was purified as the monohydrochloride and the molecular formula was proposed to be C22H30N8O11.HCl. The antibiotic gave histidine by acid hydrolysis. Histidinomycin showed rather narrow antimicrobial spectrum for only few genera o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 29 1 شماره
صفحات -
تاریخ انتشار 1976