The evaluation of rabbits model in bearing VX2 hepatic tumors by multi-slice spiral CT perfusion and real-time contrast enhanced ultrasonography and the correlation research of VEGF
ثبت نشده
چکیده
منابع مشابه
The evaluation of anti-angiogenic effects of Endostar on rabbit VX2 portal vein tumor thrombus using perfusion MSCT
BACKGROUND There were many treatments for hepatocellular carcinoma with portal vein tumor thrombus (PVTT), in which targeted anti-angiogenic drug therapy is becoming a popular research topic. However, an objective and non-invasive method that can evaluate the treatment effects is still lacking. METHODS Eighteen New Zealand white rabbits implanted with VX2 tumor thrombus in portal vein were ra...
متن کاملA Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
Objective: The purpose of this study was to evaluate the correlation between CT perfusion parameters and the hypoxia-inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and microvessel density (MVD) marked by CD34 molecular of rabbit VX2 liver tumors and to investigate the value of CT perfusion imaging in evaluating tumor angiogenesis...
متن کاملEvaluating the effect of high-intensity focused ultrasound therapy on liver tumors using multislice CT perfusion
The aim of this study was to investigate the changes of the multislice computed tomography (MSCT) perfusion parameters and histopathology of the liver in rabbits with VX2 tumors before and after high-intensity focused ultrasound (HIFU) therapy. VX2 carcinoma cells were implanted into the livers of eight New Zealand white rabbits 3 weeks prior to the treatment. MSCT perfusion was performed one w...
متن کاملEarly quantification of the therapeutic efficacy of the vascular disrupting agent, CKD-516, using dynamic contrast-enhanced ultrasonography in rabbit VX2 liver tumors
PURPOSE To evaluate the usefulness of dynamic contrast-enhanced ultrasonography (DCE-US) in the early quantification of hemodynamic change following administration of the vascular disrupting agent (VDA) CKD-516 using a rabbit VX2 liver tumor model. METHODS This study was approved by our institutional animal care and use committee. Eight VX2 liver-tumor-bearing rabbits were treated with intrav...
متن کاملOptimization of Parameters in 16-slice CT-scan Protocols for Reduction of the Absorbed Dose
Introduction In computed tomography (CT) technology, an optimal radiation dose can be achieved via changing radiation parameters such as mA, pitch factor, rotation time and tube voltage (kVp) for diagnostic images. Materials and Methods In this study, the brain, abdomen, and thorax scaning was performed using Toshiba 16-slice scannerand standard AAPM and CTDI phantoms. AAPM phantom was used for...
متن کامل