Mix and Match: Heterodimers and Opioid Tolerance
نویسندگان
چکیده
Heterodimerization of G-protein coupled receptors has become increasingly recognized as a valuable mechanism to increase receptor diversity. Heterodimers have been observed in the opioid receptor family, but one of the most intriguing is that formed between mu and delta opioid receptors. In this issue of Neuron He et al. present evidence further implicating these heterodimers in morphine tolerance.
منابع مشابه
Spinal interaction between μ and δ opioid receptors in naive and morphine-tolerant rats
Background The role of δ opioid receptors in opioid antinociception and tolerance development is still unclear. In the spinal cord of morphine-tolerant mice δ receptor ligands given intrathecally (i.t.) differently influenced the antinociceptive effect of the μ agonist D-Ala2-methyl-glycinol (DAMGO). The δ1 agonist D-Pen2,5-enkephalin (DPDPE) inhibited, the δ2 agonist deltorphin II did not alte...
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ورودعنوان ژورنال:
- Neuron
دوره 69 شماره
صفحات -
تاریخ انتشار 2011