lysosomal-enzyme release in cultured mouse calvaria
نویسنده
چکیده
The effect of bradykinin on bone resorption was studied in cultures of newbornmouse calvaria. Bradykinin (0.03,UM, 1 Mm) stimulated the release of 4'Ca2+ from bones dissected out from mice prelabelled in vivo with 45Ca. Bradykinin (1 Mm) also augmented the release of stable calcium (4"Ca), Pi and the lysosomal enzyme f,glucuronidase. The stimulatory effect of bradykinin on mineral mobilization and lysosomal-enzyme release could be blocked by indomethacin. It is speculated that concomitant generation of thrombin and bradykinin in areas of trauma and inflammation may induce resorption of nearby bone tissue.
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