Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin.
نویسندگان
چکیده
Mice with genetic muscular dystrophy were treated with intraperitoneal injections of the proteinase inhibitor leupeptin, beginning before the onset of weakness. A significant number of the treated animals failed to develop histological evidence of dystrophy, compared with controls. Leupeptin treatment prevented (or delayed) the onset of muscular dystrophy in this experiment.
منابع مشابه
Leupeptin-based inhibitors do not improve the mdx phenotype.
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 78 12 شماره
صفحات -
تاریخ انتشار 1981