Ginossar Decoding Human Cytomegalovirus
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MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D. A microRNA encoded by human cytomegalovirus downregulates MICB expression by targeting a specific site in the MICB 3¢ untranslated region. As this site is conserved among different MICB alleles and a similar site exists in the MICA 3¢ untranslated region, we speculated that these sites are targeted by cellular...
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