Interferon-induced sarcoidosis with osseous involvement in a patient with melanoma.

To the Editor: Interferons are widely used in the treatment of both malignant and nonmalignant diseases. One rare complication, attributable to the immunomodulatory effect of interferon (IFN) treatment is the triggering or exacerbation of sarcoidosis [1]. We present the scintigraphic and radiographic imaging findings of a patient that developed sarcoidosis with bone involvement mimicking metastatic disease during the course of adjuvant IFN-alpha treatment for malignant melanoma. A 32 years old woman was diagnosed with a superficial left tibial melanoma, metastatic to the inguinal lymph nodes (Clark level IV; Breslow tumor thickness 1.82mm). Since the primary tumour had more than 0.75mm thickness the patient underwent re-excision of the primary lesion with radioguided sentinel lymph node biopsy [2], which was positive for micrometastases and subsequently underwent dissection of