Retraction: 'An endogenous, systemic RNAi pathway in plants'.

Following an investigation conducted by the The EMBO Journal, the corresponding authors were alerted of several image irregularities found in this paper. Patrice Dunoyer, who assembled the figures, acknowledges making the following errors during their preparation and that the other co-authors were unaware of them: • Figure 3C (@GFP blot): Incorrect splicing of the blot led to a duplicated band improperly used for the final figure. Two dividers should have been also added to clearly indicate splicing of the original blot. • Figure 3C (@IR71 blot): Background duplication was done during image editing instead of putting a divider between the dcl234 samples and the col0 samples to indicate splicing of the original blot. • Figure 4A (@2039 blot): The blot shown in the right-hand side panel of the figure (col0, O. pumila, C. rubella samples) is a duplication of the @2039 signal of the three-first samples of the middle panel. In addition, duplicated sections in the middle panel @2039 were used to cover background noise. The first two and the last two lanes of the loading control (4A, middle panel) are duplicated and mirrored. • Figure 4D and Supplementary Figure S3: The rRNA loading controls displayed are not the cognate ones. Detection of miR159, whose accumulation is unaltered by the mutations shown in Supplementary Figure S3, provides an internal control for equal loading in these experiments. All authors consider that the core conclusions of the published paper remain valid; graft transmission of endogenous siRNAs has been confirmed in several independent studies. However, the authors admit that integrity of the scientific literature is compromised by the data manipulation and are therefore requesting the article to be retracted. Olivier Voinnet and Patrice Dunoyer take full responsibility for having allowed the publication of this flawed article. All authors concur with this statement and wish to apologize for the inconvenience caused.