Effects of Curcumin Attenuated Hepatitis in Mice with Paracetamol Overdose

Background: N-acetyl-p-aminophenol (APAP) or paracetamol overdose causes increasing of toxic metabolites, which disrupting hepatocyte function, and liver injury occurs. Curcumin has been used for treatment of inflammatory conditions such as hepatitis. Therefore, this study aims to determine effects of curcumin attenuate hepatitis in mice with APAP overdose. Methods: Male mice (25-30 gram) were divided into four groups. Group I (control); mice were gavaged with distilled water. Group II (APAP); mice were gavaged with a single dose of 400 mg/kg of APAP. Group III (APAP + CUR 200); mice were gavaged with a single dose of 400 mg/kg of APAP and 200 mg/kg of curcumin. Group IV (APAP + CUR 600); mice were gavaged with a single dose of 400 mg/kg of APAP and 600 mg/kg of curcumin. The serum was collected to determine liver enzymes and liver tissues for hepatic MDA, hepatic GSH