Full-brain coverage and high-resolution imaging capabilities of passband b-SSFP fMRI at 3T.

نویسندگان

  • Jin Hyung Lee
  • Serge O Dumoulin
  • Emine U Saritas
  • Gary H Glover
  • Brian A Wandell
  • Dwight G Nishimura
  • John M Pauly
چکیده

Passband balanced-steady-state free precession (b-SSFP) fMRI is a recently developed method that utilizes the passband (flat portion) of the b-SSFP off-resonance response to measure MR signal changes elicited by changes in tissue oxygenation following increases in neuronal activity. Rapid refocusing and short readout durations of b-SSFP, combined with the relatively large flat portion of the b-SSFP off-resonance spectrum allows distortion-free full-brain coverage with only two acquisitions. This allows for high-resolution functional imaging, without the spatial distortion frequently encountered in conventional high-resolution functional images. Finally, the 3D imaging compatibility of the b-SSFP acquisitions permits isotropic-voxel-size high-resolution acquisitions. In this study we address some of the major technical issues involved in obtaining passband b-SSFP-based functional brain images with practical imaging parameters and demonstrate the advantages through breath-holding and visual field mapping experiments.

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عنوان ژورنال:
  • Magnetic resonance in medicine

دوره 59 5  شماره 

صفحات  -

تاریخ انتشار 2008