No Increase in Endogenous Bone Mass by Overexpression of BMP Signaling through BMP Type IA Receptor BMPRIA(ALK3) in Osteoblasts
نویسندگان
چکیده
Bone morphogenetic proteins (BMPs) are known as ectopic bone inducers. The FDA approved BMPs (BMP2 and BMP7) for clinical use. However, direct effects of BMPs on endogenous bone metabolism are not yet well known. We recently reported that loss of BMPRIA (ALK3), a potent receptor for BMP2 and BMP4, in osteoblasts unexpectedly increased endogenous bone mass during embryonic and adult stages (ref 1-3).
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