DYSFUNCTIONAL CD39 REGULATORY T CELLS AND ABERRANT CONTROL OF T HELPER TYPE 17 CELLS IN AUTOIMMUNE HEPATITIS Short title: CD39 REGULATORY T CELLS IN AUTOIMMUNE HEPATITIS
نویسندگان
چکیده
Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.
منابع مشابه
IMMUNOBIOLOGY Notch1 and TGF 1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells
Notch and its ligands have been implicated in the regulation and differentiation of various CD4 T-helper cells. Regulatory T cells (Tregs), which express the transcription factor Foxp3, suppress aberrant immune responses that are typically associated with autoimmunity or excessive inflammation. Previous studies have shown that transforming growth factor beta (TGF 1) induces Foxp3 expression and...
متن کاملEnforced Expression of CXCR5 Drives T Follicular Regulatory-Like Features in Foxp3+ T Cells
CXCR5+ T follicular helper (Tfh) cells are associated with aberrant autoantibody production in patients with antibody-mediated autoimmune diseases including lupus. Follicular regulatory T (Tfr) cells expressing CXCR5 and Bcl6 have been recently identified as a specialized subset of Foxp3+ regulatory T (Treg) cells that control germinal center reactions. In this study, we show that retroviral tr...
متن کاملOptimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.
Recently, a new lineage of CD4+ T cells has been described in the mouse that specifically secretes IL-17 [T helper (Th) 17]. This discovery has led to a revision of the hypothesis that many autoimmune diseases are predominantly a Th1 phenomenon and may instead be critically dependent on the presence of Th17 cells. Murine Th17 cells differentiate from naïve T cell precursors in the presence of T...
متن کاملDisturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is an autoimmune disease accompanied by disturbed T-cell homeostasis. Dysbalance of T-helper-cell (Th) subsets (Th1/Th2/Th17) and regulatory T-cells (T(regs)) is suggested to contribute to the pathogenesis of SLE. Recent reports suggest functional deviation of T(regs) in terms of producing IL-17A, a process that may be aberrant in SLE. Therefore, we analyzed t...
متن کاملControl of Dichotomic Innate and Adaptive Immune Responses by Artery Tertiary Lymphoid Organs in Atherosclerosis
Tertiary lymphoid organs (TLOs) emerge in tissues in response to non-resolving inflammation such as chronic infection, graft rejection, and autoimmune disease. We identified artery TLOs (ATLOs) in the adventitia adjacent to atherosclerotic plaques of aged hyperlipidemic ApoE(-/-) mice. ATLOs are structured into T cell areas harboring conventional dendritic cells and monocyte-derived DCs; B cell...
متن کامل