Normal systemic iron homeostasis in mice with macrophage - 1 specific deletion of transferrin receptor 2
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چکیده
Normal systemic iron homeostasis in mice with macrophage1 specific deletion of transferrin receptor 2 2 Gautam Rishi, Eriza S. Secondes, Daniel F. Wallace, V. Nathan 3 Subramaniam 4 1 Membrane Transport Laboratory, QIMR Berghofer Medical Research Institute, 5 Brisbane, Queensland, 4006, Australia. 6 2 School of Medicine, The University of Queensland, Brisbane, Queensland, 4006, 7 Australia. 8 9 10 Running head: Macrophage Tfr2 is not required for systemic iron 11 homeostasis 12 13 Corresponding author 14 Professor V. Nathan Subramaniam 15 QIMR Berghofer Medical Research Institute 16 300 Herston Road, Brisbane, Queensland, 4006, Australia. 17 Tel: +617 3362 0179; Fax: +617 3362 0191 18 E-mail: [email protected] 19 20 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (November 25, 2015). doi:10.1152/ajpgi.00291.2015
منابع مشابه
Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2.
Iron is an essential element, since it is a component of many macromolecules involved in diverse physiological and cellular functions, including oxygen transport, cellular growth, and metabolism. Systemic iron homeostasis is predominantly regulated by the liver through the iron regulatory hormone hepcidin. Hepcidin expression is itself regulated by a number of proteins, including transferrin re...
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Iron-regulatory proteins (IRPs) 1 and 2 posttranscriptionally regulate expression of transferrin receptor (TfR), ferritin, and other iron metabolism proteins. Mice with targeted deletion of IRP2 overexpress ferritin and express abnormally low TfR levels in multiple tissues. Despite this misregulation, there are no apparent pathologic consequences in tissues such as the liver and kidney. However...
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Iron regulatory protein 2 (IRP2)-deficient mice have been reported to suffer from late-onset neurodegeneration by an unknown mechanism. We report that young adult Irp2-/- mice display signs of iron mismanagement within the central iron recycling pathway in the mammalian body, the liver-bone marrow-spleen axis, with altered body iron distribution and compromised hematopoiesis. In comparison with...
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BACKGROUND AND OBJECTIVES The soluble transferrin receptor (sTfR) is a clinical marker of erythropoietic activity, also used in the diagnosis of iron deficiency. In the present paper we explore the meaning of this parameter in normal physiological conditions of iron homeostasis and in the setting of iron overload due to hereditary hemochromatosis (HH). DESIGN AND METHODS Reference values for ...
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Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer TFR1, is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1. TFR2 gene is mutated in type 3 hemochromatosis, a disorder characterized by iron overload and inability to upregulate hepcidin in response to iron. Liver TFR2 is considered a sensor o...
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