New techniques in antimicrobial photodynamic therapy: scope of application and overcoming drug resistance in nosocomial infections
نویسندگان
چکیده
Given the ever increasing problem of antibiotic resistance in nosocomial pathogens it is important to promote alternate technologies that may be more affective than current antibiotics. This article reviews Photodynamic Antimicrobial Chemotherapy (PACT), a technology based on the use of a photosensitizer activated by visible light illumination and found to be effective against most types of microbial pathogens, including those resistant to antibiotics. PACT nonetheless has certain limitations, particularly against internal and blood-borne infections. To this end, we are developing Chemiluminescent Photodynamic Antimicrobial Therapy (CPAT). This review also summarizes our recent data on CPAT. The practical advantages of CPAT emphasize that this novel technique could expand efforts to control nosocomial pathogens, including those responsible for systemic infections.
منابع مشابه
کاربرد فتودینامیک تراپی در عفونتهای موضعی
Photodynamic therapy (PDT) was discovered over one hundred years ago by observing the killing of microorganisms when harmless dyes and visible light were combined in vitro. Since then it has primarily been developed as a treatment for cancer, ophthalmologic disorders and in dermatology. However in recent years interest in the antimicrobial effects of PDT has revived and it has been proposed as ...
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