A New PCR-RFLP Method for Diagnosing PNPLA3 rs738409 Polymorphism
نویسنده
چکیده
Article ID: WMC002401 Article Type: Research Protocol Submitted on:01-Nov-2011, 12:31:07 PM GMT Published on: 02-Nov-2011, 05:42:47 PM GMT Article URL: http://www.webmedcentral.com/article_view/2401 Subject Categories:GENETICS
منابع مشابه
PNPLA3 and TNF-α G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD
Introduction: There is growing evidence that genetic and environmental factors play an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). We investigated the association of single nucleotide polymorphism (SNP) rs738409 in PNPLA3 gene and TNF-α G238A polymorphism with the development and severity of NAFLD in an overweight and obese Egyptian population...
متن کاملAssociation of rs738409 Polymorphism in the PNPLA3 Gene with Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated incidence of 20%–30% in the general population and 67%–75% in the obese population. Genetic predisposition can play an important role in development of this disease. Nonsynonymous coding SNP rs738409 C/G (I148Met) in the PNPLA3 gene has been found to be associated with the presence of...
متن کاملCorrelation Between Patatin-Like Phospholipase Domain-Containing Protein 3 Gene Polymorphisms and Liver Cirrhosis in a Chinese Han Population With Chronic Hepatitis B
BACKGROUND A single nucleotide polymorphism (SNP) of patatin-like phospholipase domain-containing 3 (PNPLA3) genes (rs738409) is associated with the severity of fibrosis and cirrhosis in patients with fatty liver disease. However, in a small group of Italian patients, there was no significant correlation between the rs738409 SNP and hepatitis B virus (HBV) infection-associated liver cirrhosis. ...
متن کاملThe rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C
BACKGROUND Prospective studies have shown that 80% of acute hepatitis C virus (HCV) cases progress to chronic infection; approximately 10-20% of patients with these conditions will develop liver cirrhosis within 2 to 3 decades, and 1-5% will develop liver cancer. Some studies have indicated that the rs738409 polymorphism of the PNPLA3 gene is associated with steatosis and the progression of adv...
متن کاملبررسی ارتباط پلی مورفیسم rs738409 ژن PNPLA3 با کبد چرب غیر الکلی در جمعیت جنوب ایران
زمینه و هدف: بیماری کبد چرب غیر الکلی ( NAFLD ( طیفی از استئاتوز ساده تا سرطان کبد می باشد. در این بیماری علاوه بر عوامل زیست محیطی ، عوامل ژنتیکی نیز نقش مهمی دارند. پلی مورفیسم تک نوکلئوتیدی ) C>G ) rs738409 ژن PNPLA3 با افزایش محتوای چربی کبدی و آسیب های کبدی در اختلالات متابولیک همراه است. این مطالعه، ارتباط بین این پلی مورفیسم با بیماری کبد چرب غیر الکلی و پارامترهای دموگرافیکی و بالینی در...
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