The role of incretin-based therapies in the management of type 2 diabetes.

Incretin System in the Pathogenesis of Type 2 Diabetes and the Role of Incretin Based Therapies in the Management of Type 2 Diabetes

Integrating incretin-based therapy into type 2 diabetes management.

LEARNING OBJECTIVES 1. Explain the concept of the incretin effect and describe defects in incretin secretion and incretin action that occur in type 2 diabetes mellitus (T2DM) 2. Provide an overview of the rationale and role of incretin-based therapy as described in current practice guidelines for the management of patients with T2DM 3. Compare the efficacy, safety, and tolerability of the incre...

Managing recent-onset diabetes: choosing durable, well-tolerated therapies and understanding the role of incretin-based therapies.

Management of recent-onset diabetes offers osteopathic physicians the opportunity to work with patients to set treatment goals and expectations for this progressive yet manageable disease, as well as intervene early to reduce the risk of diabetes-related complications. Starting effective therapy early--and intensifying therapy appropriately--to achieve and maintain glycemic goals has been shown...

Potentials of incretin‐based therapies in dementia and stroke in type 2 diabetes mellitus

Patients with type 2 diabetes mellitus are at risk for accelerated cognitive decline and dementia. Furthermore, their risk of stroke is increased and their outcome after stroke is worse than in those without diabetes. Incretin-based therapies are a class of antidiabetic agents that are of interest in relation to these cerebral complications of diabetes. Two classes of incretin-based therapies a...

Emerging role of insulin with incretin therapies for management of type 2 diabetes

Type 2 diabetes mellitus (T2DM) is a progressive disease warranting intensification of treatment, as beta-cell function declines over time. Current treatment algorithms recommend metformin as the first-line agent, while advocating the addition of either basal-bolus or premixed insulin as the final level of intervention. Incretin therapy, including incretin mimetics or enhancers, are the latest ...