Oralna bulozna erupcija uzrokovana azitromicinom Bullous Oral Eruptions Caused by Azithromycin
نویسندگان
چکیده
Adresa za dopisivanje Prof.dr.sc. Marinka Mravak–Stipetić Sveučilište u Zagrebu Stomatološki fakultet Zavod za oralnu medicinu Gundulićeva 5 HR-10 000 Zagreb Tel: 01/4802 114 [email protected] Sažetak Makrolidi se smatraju najsigurnijom skupinom antibiotika i imaju vrlo nisku učestalost alergijskih reakcija (0,4 do 3 %). Opisali smo slučaj mladog pacijenta kod kojega se razvila bulozna erupcija na obraznoj sluznici i usnama nakon ingestije treće doze azitromicina. Nakon terapije kortikosteroidima lezije su se počele povlačiti, ali četvrti dan pojavila se na sluznici usne šupljine nova bulozna erupcija slabijeg intenziteta. To se može objasniti dugim vremenom poluraspada azitromicina u plazmi. Naime, taj se lijek može otkriti u lizatu neutrofila 28 dana nakon posljednje doze, što može biti povezano s većim rizikom od popratnih pojava. Prema našim spoznajama i dostupnim podacima iz literature, to je prvi opisani slučaj oralne erupcije u tijeku liječenja azitromicinom. Unatoč činjenici da azitromicin ostaje jedan od makrolida koji se najbolje toleriraju, ponekad može prouzročiti ozbiljne nuspojave.
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