Vascular Development and Vessel Remodelling Association between TAFI antigen and Ala147Thr polymorphism of the TAFI gene and the angina pectoris incidence The PRIME Study
نویسندگان
چکیده
Pierre E. Morange1, Irène Juhan-Vague1, Pierre Y. Scarabin2, Marie C. Alessi1, Gérald Luc3, Dominique Arveiler4, Jean Ferrieres5, Philippe Amouyel6, Alun Evans7, Pierre Ducimetiere2 on behalf of the PRIME Study group 1Department of Hematology, Hôpital de la Timone, INSERM 99–36 Marseilles, France 2INSERM U258,Villejuif, France 3Department of Atherosclerosis, INSERM UR545, Institut Pasteur de Lille, Lille, France 4The Strasbourg MONICA Project, Department of Epidemiology and Public Health, Faculty of Medicine, Strasbourg, France 5The Toulouse MONICA Project, INSERM U588, Department of Epidemiology, Paul Sabatier-Toulouse Purpan University, Toulouse, France 6The Lille MONICA Project, INSERM U508, Institut Pasteur de Lille, France 7The Department of Epidemiology and Public Health, Queen’s University of Belfast, Northern Ireland
منابع مشابه
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Identification of polymorphisms in the promoter and the 39 region of the TAFI gene: evidence that plasma TAFI antigen levels are strongly genetically controlled
Thrombin-activable fibrinolysis inhibitor (TAFI) is a recently described carboxypeptidase that is potentially involved in the regulation of fibrinolysis by decreasing plasminogen binding to the fibrin surface. This role makes the TAFI gene a good candidate in atherothrombotic diseases. The great interindividual variability of plasma TAFI antigen levels is poorly explained by lifestyle character...
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The thrombin-activatable fibrinolysis inhibitor (TAFI) is a recently described inhibitor of fibrinolysis that decreases plasminogen binding to the fibrin surface. The plasma TAFI concentration is almost entirely genetically determined. We investigated whether plasma TAFI levels and polymorphisms located in the TAFI gene could constitute risk markers of myocardial infarction (MI). Plasma TAFI an...
متن کاملIdentification of polymorphisms in the promoter and the 3' region of the TAFI gene: evidence that plasma TAFI antigen levels are strongly genetically controlled.
Thrombin-activable fibrinolysis inhibitor (TAFI) is a recently described carboxypeptidase that is potentially involved in the regulation of fibrinolysis by decreasing plasminogen binding to the fibrin surface. This role makes the TAFI gene a good candidate in atherothrombotic diseases. The great interindividual variability of plasma TAFI antigen levels is poorly explained by lifestyle character...
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INTRODUCTION In patients with coronary disease at risk of acute coronary events it is unclear which biological factors could predict the type of acute coronary syndrome clinical presentation. The aim of the study was to investigate the role of genetic polymorphisms in key proteins in fibrinolysis in the type of acute coronary syndrome. MATERIALS AND METHODS 248 patients with acute coronary sy...
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OBJECTIVE Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis. The aim of the present study was to investigate the possible association between TAFI and overall ischemic stroke and ischemic stroke subtypes. METHODS AND RESULTS The Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) comprises 600 cases (18 to 69 years) and 600 matched population controls. Stroke subty...
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