Early clinical experience with a newly formulated hydroxyethyl starch--Hextend.
نویسندگان
چکیده
منابع مشابه
Hydroxyethyl starch in balanced electrolyte solution (Hextend)--pharmacokinetic and pharmacodynamic profiles in healthy volunteers.
UNLABELLED Hextend is a new plasma volume expander containing 6% hydroxyethyl starch (HES) in a physiologically balanced medium of electrolytes, glucose, and lactate (weight average, molecular weight 670 kDa, molar substitution 0.75). This open-label study was designed to investigate the pharmacokinetic and pharmacodynamic profiles of Hextend in 21 healthy volunteers. We infused Hextend 10 ml/k...
متن کاملPerioperative clinical and economic outcomes associated with replacing first-generation high molecular weight hydroxyethyl starch (Hextend®) with low molecular weight hydroxyethyl starch (Voluven®) at a large medical center
BACKGROUND Several plasma volume expander alternatives exist to enhance intravascular volume status in patients undergoing surgery. The optimal intravascular volume expander in the perioperative setting is currently unknown. Low molecular weight hetastarch, Voluven® (130/0.4), may have a better safety profile than high molecular weight hetastarch, Hextend® (450/0.7). We examined the clinical an...
متن کاملIntra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage
BACKGROUND Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation with hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined. METHODS Using a retrospective cohort of neuro...
متن کاملEffects of a new modified balanced hydroxyethyl starch preparation (Hextend) on measures of coagulation.
BACKGROUND Hydroxyethyl starch (HES) may affect blood coagulation. We studied the effects of a modified, balanced, high-molecular weight [mean molecular weight (MW) 550 kDa], high-substituted [degree of substitution (DS) 0.7] HES preparation (Hextend) on coagulation in patients undergoing major abdominal surgery. METHODS Patients were allocated randomly to receive Hextend) (n=21), lactated Ri...
متن کاملHemodynamic Variables and Tissue Energetics during Resuscitation of Porcine Hemorrhagic Shock with Hextend or Lactated Ringer’s Solution
There has been recent interest in resuscitation of hemorrhagic shock using new colloid solutions such as Hextend (6% hydroxyethyl starch in balanced salt solution). We examined the effects of resuscitation of porcine hemorrhagic shock with Hextend or lactated Ringer’s (LR) solution on hemodynamic parameters and tissue energetics. Anesthetized, instrumented pigs underwent hemorrhagic shock (35% ...
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 82 2 شماره
صفحات -
تاریخ انتشار 1999