8.4 Novel autoantibodies targeting a p140 protein are a major autoantigen system in juvenile dermatomyositis and a marker of calcinosis
نویسندگان
چکیده
Address: 1Rheumatology Department, Royal National Hospital for Rheumatic Diseases, Bath, UK, 2Rheumatology Unit, Institute of Child Health, London, UK, 3School for Health, University of Bath, Bath, UK, 4Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK, 5Rheumatic Diseases Centre, Hope Hospital, Salford, UK, 6Rheumatology Department, Bristol Royal Hospital for Children, Bristol, UK and 7Rheumatology Department, Royal Liverpool Children's Hospital, Liverpool, UK * Corresponding author
منابع مشابه
Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis
OBJECTIVE The identification of novel autoantibodies in juvenile dermatomyositis (DM) may have etiologic and clinical implications. The aim of this study was to describe autoantibodies to a 140-kd protein in children recruited to the Juvenile DM National Registry and Repository for UK and Ireland. METHODS Clinical data and sera were collected from children with juvenile myositis. Sera that re...
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PURPOSE OF REVIEW Over the last few years, there have been several collaborative efforts focusing on how to assess the many aspects of juvenile dermatomyositis (JDM). It has become apparent that skin manifestations are an important part of the disease process that need to be evaluated, treated and controlled. Other extramuscular manifestations, such as calcinosis, are particularly difficult to ...
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Objective. Calcinosis is a major cause of morbidity in JDM and has previously been linked to anti-NXP2 autoantibodies, younger age at disease onset and more persistent disease activity. This study aimed to investigate the clinical associations of anti-NXP2 autoantibodies in patients with JDM stratified by age at disease onset. Methods. A total of 285 patients with samples and clinical data were...
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