Cu(atsm) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in an Amyotrophic Lateral Sclerosis Mouse Model
نویسندگان
چکیده
Background: Cu(atsm) [(diacetylbis(N(4)methylthiosemicarbazonato) copper(II)] was orally administrated to transgenic SOD1 mice. Results: Treatment significantly prolonged lifespan with preservation of motor neurons. Reduced protein oxidation, attenuated astrocyte and microglial activation also resulted from treatment. Conclusion: Cu(atsm) is neuroprotective in this model even when treatment begins after the onset of disease symptoms. Significance: The drug has therapeutic potential for amyotrophic lateral sclerosis.
منابع مشابه
Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.
Amyotrophic lateral sclerosis (ALS) is a progressive paralyzing disease characterized by tissue oxidative damage and motor neuron degeneration. This study investigated the in vivo effect of diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)), which is an orally bioavailable, blood-brain barrier-permeable complex. In vitro the compound inhibits the action of peroxynitrite on Cu,Z...
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