Influence of s-allyl cysteine against mercuric chloride induced nephrotoxicity in albino rats

Mercury (II) is a highly toxic metal which induced oxidative stress in the living organism. In the present study we examined the effect of S-Allyl cysteine (SAC) against the mercuric chloride (Hgcl2) intoxicated in albino rat model. The animals were treated with sub-leathal dose of mercuric chloride (1.23 mg/kg body wt) for 7 days. After scheduled treatetment the animals were decapitated and whole kidney tissue was used for the determination of biochemical and bioenzymological assays like lipid peroxidation (LPO) glutathione (GSH), Glutathione peroxidase (GPx), Catalase(CAT), and Superoxide dismutase (SOD) levels. During the mercuric chloride treatment the level of LPO content was significantly increased and simultaneously the level of reduced glutathione (GSH), Glutathione peroxidase (GPx), Catalase (CAT), and Superoxide dismutase (SOD) activities were decreased. The results revealed that HgCl2 induced oxidative stress and cell damage. During the recovery period, S-Allyl cysteine (5 mg/kg body wt) administrated for another 7 days on mercury intoxicated rat kidney tissue showed the decreased the level of LPO content and also restore the antioxidant level. The result suggested that HgCl2 mainly induced oxidative cell damage in kidney and administration of S-Allyl Cysteine on mercury intoxicated animal can get protection with its antioxidant effects.