Supporting Information Dynamic Light Scattering
نویسندگان
چکیده
Changes in the size of the aptamer-conjugated AuNPs upon binding to the viruses were observed by dynamic light scattering (DLS). Changes in the size of scattering particles using DLS when the AuNP.virus complexes are formed has previously been reported by Driskell et al. using antibodies conjugated to 30, 60, 80nm AuNPs.[1] For a direct comparison with their work we used AuNPs of similar diameters (20nm, 80nm) conjugated with the aptamers. Moreover, using larger AuNPs for DLS experiments, as compared to the 5nm NPs depicted in Figure 1, gives a clearer distinction between the AuNPs.virus and the unconjugated virus (100nm). Calculations based on close packing of these NP’s suggest that each virus particle could accommodate 200 NPs of 20nm diameter or 12 NPs of 80nm diameter on their surface.
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