A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report
نویسندگان
چکیده
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.
منابع مشابه
Osteonecrosis Related to Oral Bisphosphonate Usage: Case Report and Review of Treatment Strategies
Bisphosphonates are a class of agents used to treat osteoclast-mediated bone diseases and many neoplasm types. Osteonecrosis of the jaw is a common side effect of bisphosphonate therapy, presenting as exposed and necrotic maxillary and/or mandibular bone. In this report, we present a case of bisphosphonate-related osteonecrosis of the jaw in a patient who received oral alendronate therapy due t...
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Although pathophysiology, incidence, and factors associated with the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and management strategies for patients treated with bisphosphonates or patients with BRONJ are well-established, few guidelines or recommendations are available for patients with a history of successfully healed BRONJ. We present a case of successful dental...
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