Induction of HIV blocking anti - CCR 5 IgA in Peyers ’ s Patches 1 without histopathological alterations
نویسندگان
چکیده
1 Division of Immunology, Transplantation and Infectious Diseases, San Raffaele 9 Scientific Institute, Milan, Italy 10 2 Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, 11 PA, US 12 3 Inserm, U1016, Institut Cochin, Paris, France 13 4 CNRS UMR 8104, Paris, France 14 5 Entrée Muqueuse du VIH et Immunité Muqueuse Institut Cochin, Univ. Paris 15 Descartes Cité Paris Sorbonne, Paris, France 16 6 Pathology Department, Mouse Histopathology Unit, San Raffaele Scientific 17 Institute, Milan, Italy 18 # Corresponding author 19 8 These authors contributed equally 20 21 22 Running title: HIV protective CCR5 specific IgA 23 24 25 Corresponding author: [email protected] 26 27 28 29 JVI Accepts, published online ahead of print on 8 January 2014 J. Virol. doi:10.1128/JVI.03663-13 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations.
UNLABELLED The chemokine receptor CCR5 is essential for HIV infection and is thus a potential target for vaccine development. However, because CCR5 is a host protein, generation of anti-CCR5 antibodies requires the breaking of immune tolerance and thus carries the risk of autoimmune responses. In this study, performed in mice, we compared 3 different immunogens representing surface domains of m...
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