Time to energize coenzyme Q10 for patients with heart failure?
نویسنده
چکیده
Energy generation and utilization have been the focal points of many research groups trying to elucidate the pathways, deficiencies, and enhancement of the energy-generation centers of the cell, the mitochondria (2). In mitochondrial function, coenzyme Q10 (CoQ10; ubiquinone) has a unique function in oxidative phosphorylation and the generation of adenosine triphosphate (3). The myocardial and skeletal muscle cells of patients with heart failure (HF) are in an energy-starved state; hence any increase in the ability to augment energy production or enhance efficient utilization is certain to have positive functional effects.
منابع مشابه
Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials
BACKGROUND The therapeutic efficacy of coenzyme Q10 on patients with cardiac failure remains controversial. We pooled previous clinical studies to re-evaluate the efficacy of coenzyme Q10 in patients with cardiac failure. METHODS We searched PubMed, Cochrane Library, EMBASE, and Clinical Trials.gov databases for controlled trials. The endpoints were death, left heart ejection fraction, exerci...
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ورودعنوان ژورنال:
- JACC. Heart failure
دوره 2 6 شماره
صفحات -
تاریخ انتشار 2014