Time to energize coenzyme Q10 for patients with heart failure?

نویسنده

  • Justin A Ezekowitz
چکیده

Energy generation and utilization have been the focal points of many research groups trying to elucidate the pathways, deficiencies, and enhancement of the energy-generation centers of the cell, the mitochondria (2). In mitochondrial function, coenzyme Q10 (CoQ10; ubiquinone) has a unique function in oxidative phosphorylation and the generation of adenosine triphosphate (3). The myocardial and skeletal muscle cells of patients with heart failure (HF) are in an energy-starved state; hence any increase in the ability to augment energy production or enhance efficient utilization is certain to have positive functional effects.

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عنوان ژورنال:
  • JACC. Heart failure

دوره 2 6  شماره 

صفحات  -

تاریخ انتشار 2014