Medicines Evidence Commentary commentary on important new evidence from Medicines Awareness Weekly Published: December 2015 Pregnancy: Effect of metformin on pregnancy outcomes in obese women without diabetes (EMPOWaR study)
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چکیده
The results of a UK randomised controlled trial suggest that metformin taken by nondiabetic obese women during pregnancy has no statistically significant effect on neonatal birthweight or other maternal and neonatal secondary outcomes compared with placebo. Maternal diarrhoea and vomiting were more common with metformin. This study supports NICE guidance on weight management before, during and after pregnancy, which considered dietary and physical activity interventions. Off-label use of metformin was not included in the scope of the guideline.
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Efficacy of metformin in pregnant obese women: a randomised controlled trial
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