High Sensitive C - reactive protein – A Risk Marker For Coronary Artery Disease

Abstract : Background of the study Coronary Artery Disease (CAD) remains the leading cause of morbidity and mortality in the present world. Clinical and laboratory studies have shown that inflammation plays a major role in the initiation, progression, and destabilization of atheromas. C-reactive protein (CRP), an acute phase reactant that reflects low-grade systemic inflammation, has been studied in a variety of cardiovascular diseases. Aim: To measure high sensitive c reactive protein (hs-CRP) value in patients with coronary artery disease and to compare it with controls. Outline of previous work – previous studies have demonstrated that elevated hsCRP levels has strong correlation with coronary artery disease. Methodology – 50 subjects who were recently diagnosed as coronary artery disease (investigations already done during the period of hospitalization) were included in the study after a questionnaire analysis. Blood investigations include hs-CRP & serum lipid profile, were done during the period of hospitalization. The reports were collected and compared with the normal reference range. Results – in our study, hs-CRP, total cholesterol, and low density lipoprotein levels are significantly high in cases when compared to controls and high density lipoprotein levels are significantly low in cases when compared to controls. We observed a positive correlation between hs-CRP and lipid parameters. Conclusion – hsCRP can be considered as a risk marker for coronary artery disease.