Short-term treatment of gonorrhoea with intramuscular and oral forms of trimethoprim-sulphamethoxazole.

Simulataneous Analysis of Trimethoprim and Sulphamethoxazole Drug Combinations in Dosage Forms by High Performance Liquid Chromatography

A sensitive high performance liquid chromathography (HPLC) analytical procedure was developed for the quantitive determination of trimethoprim (TM* and sulphamethoxazole (SM) in commercial dosage forms. C18 analytical column (stainless steel, 25 cm * 4.6 mm i.d.) was packed with 5-*m particles of the reversed phase material and used for assays. Mobile phase containing 0.025 M sodium phosphate...

Sulphamethoxazole combined with 2-4-diamino-pyrimidines in the treatment of gonorrhoea.

THE synergistic action of the combination ofsulphonamides and 2-4-diamino-pyrimidine compounds against the gonococcus has been demonstrated clinically by Csonka and Knight (1967). It was decided to reassess the clinical efficacy of the combination of trimethoprim with sulphamethoxazole* in gonorrhoea, to examine its mode of action, and to compare the effect of a combination of another pyrimidin...

Trimethoprim-sulphamethoxazole in gonorrhoea. A comparison with privampicillin combined with probenecid.

419 patients with uncomplicated gonorrhoea were treated with sulphamethoxazole 4 g. combined with trimethoprim 0-8 g. divided into two doses with an 8-hr interval. The failure rate was 1-9 per cent. Parallel with this trial, 319 patients received pivampicillin 1-4 g. combined with probenecid 1 g,; the failure rate was 0-9 per cent. Side-effects were few, four patients in the first group and one...

Treatment of gonorrhoea with trimethoprim-sulphamethoxazole and probenecid plus procaine penicillin in Rwanda.

Trimethoprim-sulphamethoxazole (Septrin) in the treatment of rectal gonorrhoea.

The recent increase in some parts of London of syphilis acquired homosexually (Lancet, 1964; Brit. med. J7., 1967) has indicated that a drug of nontreponemicidal properties is to be preferred in the treatment of gonococcal proctitis in homosexual men. Septrin was considered as a potentially useful remedy in these circumstances. Though taken orally and so subject to error or misuse, it needs be ...