Pseudomonas cepacia empyema necessitatis after lung transplantation in two patients with cystic fibrosis.

Empyema in a Woman with Cystic Fibrosis: A Cautionary Tale

Cystic fibrosis (CF) is a disease which predisposes individuals to recurrent infective exacerbations of suppurative lung disease; however, empyema is a rare complication in these patients. Empyemas secondary to Staphylococcus aureus and Burkholderia cepacia have been described in patients with CF. We report the case of pleural empyema with mixed S. aureus and Pseudomonas aeruginosa infection in...

Lung donors for cystic fibrosis patients.

Lung donors for cystic fibrosis patients As a centre involved in the care of patients with cystic fibrosis both before and after transplantation, we read with considerable interest the experience of Ryan and Stable-forth of lung transplantation for their patients (March 1996;51:302-5). Their observation that one third of their patients die while awaiting transplantation in the UK is well made. ...

Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing

Early infection is a recognised complication after lung transplantation in patients with cystic fibrosis (CF). Our centre uses multiple combination bactericidal testing (MCBT) when determining appropriate peritransplant prophylactic regimens. To evaluate our strategy, we compared the incidence of posttransplant infection in patients whose peritransplant antimicrobial regimens were determined us...

Should patients with cystic fibrosis infected with Burkholderia cepacia undergo lung transplantation?

Effect of antibiotic treatment on inflammatory markers and lung function in cystic fibrosis patients with Pseudomonas cepacia.

BACKGROUND The acquisition of Pseudomonas cepacia in patients with cystic fibrosis is associated with increasing deterioration in lung function and more frequent hospital admissions. Pseudomonas cepacia is usually resistant to several antibiotics in vitro, but the response of patients colonised with the organism has not been extensively studied in vivo. METHODS A three month prospective study...