Alterations in fertility induced by unilateral intrauterine instillation of cytotoxic compounds in rats.

Biologic changes induced by unilateral intrauterine instillation of quinacrine in the rat and their reversal by either estradiol or progesterone.

In previous studies’ we have instilled cytotoxic agents and metabolic depressants into the endometrial cavity of rats, and have thereby induced changes in the endometrium which have resulted in reduced fertility. It was suggested that this reduction of fertility was due to an endometrial environment which was inadequate for implantation. Two different types of histologic changes have been obser...

Sulpiride-Induced Hyperprolactinemia in Mature Female Rats: Evidence for Alterations in The Reproductive System, Pituitary and Ovarian Hormones

Investigation of the Protective Effects of Amlodipine on the Structure and Function of Testicular Tissue following Experimental Unilateral Cryptorchidism in Rats

Objective- Cryptorchidism, common birth defect of the male genital tract, is one of the causes of fertility problems. The elevation of tissue temperature following of cryptorchidism could induce oxidative stress which influences the cellular and tissue degeneration. Amlodipine is a third-generation of calcium channel blockers which has antioxidant activity. The aim of this stud...

Aluminium-Induced Oxidative Stress, Apoptosis and Alterations in Testicular Tissue and Sperm Quality in Wistar Rats: Ameliorative Effects of Curcumin

Objective Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. No studies have evaluated the possible effects of curcumin (CUR) on Al-induced reproductive dysfunction. Therefore, this study investigated the effects of CUR treatment on Al-induced reproductive damage. MaterialsAndMethods In this experimental study, 40 male Wistar rats were allocated to five groups (N...

Comparative effects of intrauterine instillation of analogues of quinacrine and tetracycline on uterine morphology in the rat.

Currently, intrauterine instillation of quinacrine hydrochloride is used to induce closure of the uterotubal junction in women, thus constituting a chemical method of sterilization. Questions regarding the safety of this drug have been raised. The purpose of the present study is to screen other drugs for their sterilizing potential by comparing quinacrine-induced changes in uterine morphology i...