Effect of Brahmi and Neem on·gastric ulceration and healing in experimental NIDDM rats

normal! NIDDMrats by various physical (2 hrs cold restraint stress and 4 hours pylorus ligation) and chemical agents (ethanol, 1 mJ/200g, oral, 1 hr before; aspirin, 200 mglkg, oral) and duodenal ulcers were induced by cysteamine (40 mg!200g). Ulcer healing activitywas studied in gastric ulcers induced by acetic acid (50%) and HCI (0.6 M). The result indicated that in both, normal and NlDDM rats, B. monnieri extract (BME,20-100 mglkg) did not show any significant effect on blood glucose level, while A. indica (AlE, 250-1000.mg/kg) significantly decreased it. However,both BME(50 mg! kg) and AIE (500 mg/kg) showed significant anti-ulcer and ulcer-healing activities in normal and NIDDM rats. Further, the present results also indicated that the ulcer protective effects of BME were more pronounced in non-diabetic, while that ofAlEwas more in NIDDMrats. The anti-ulcer and ulcer-healing activities of BMEand AlEmay be due to their effects on various mucosal offensive and defensivefactors, and correction of blood sugar level byAlEmay help to have more ulcer protective effect in NIDDM rats [Dorababu et aI, Indian J Exp BioI, 2004, 42 (4), 389-397].