Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells.
نویسندگان
چکیده
Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes proceed with rate constants up to 3.38 ± 0.31 M(-1) s(-1) in CD(3)CN, or 59 times faster than the analogous reaction of azides. This highly specific modular labeling strategy can be applied for direct labeling of proteins and for live cell imaging of cancer cells.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 36 شماره
صفحات -
تاریخ انتشار 2011