Molecular characterization of the SHV-11 beta-lactamase of Shigella dysenteriae.
نویسندگان
چکیده
A beta-lactamase with an M(r) of 29,000 and a pI of 7.6 was partially purified from a clinical isolate of Shigella dysenteriae. The bla gene encoded the SHV-11 enzyme carrying the substitution Leu-->Gln at position 35 and was linked to a strong promoter. This variant, unlike the prototype SHV-1 enzyme, hydrolyzed oxacillin, cloxacillin, and oxyiminocephalosporins such as cefotaxime.
منابع مشابه
Determination of Antibiotic Resistance Pattern and frequency of CTX-M, TEM, and SHV Β-Lactamase Encoding Genes among Shigella Isolates from Inpatients in Tehran, Iran
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This article has no abstract. DOI: 10.18502/jfqhc.8.4.8261
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 43 8 شماره
صفحات -
تاریخ انتشار 1999