Cyclooxygenase-2 inhibitors in aspirin-sensitive asthma.
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چکیده
منابع مشابه
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Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. Effect of endobronchial aspirin challenge on inflammatory cells in bronchial biopsy samples from aspirin-sensitive asthmatic subjects. Expression of interleukin-5 and granulocyte-macrophage ...
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IN a subset of patients with asthma, nonsteroidal antiinflammatory drugs (NSAIDs) that inhibit both cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) can precipitate dangerous asthmatic attacks. It has been proposed that in these patients, the attacks are triggered by inhibition of COX-1 and not COX-2, and that the use of highly selective COX-2 inhibitors may be safe in asthmatic patients, ...
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The use of analgesic anti-inflammatory agents in patients with asthma is clinically challenging because of the prevalence (10-20%) of aspirin hypersensitivity. Aspirin-exacerbated respiratory disease (AERD), or aspirin-induced asthma, is characterized by asthma and rhinitis triggered by the ingestion of aspirin and non-steroidal anti-inflammatory drugs. AERD is associated with upper and lower r...
متن کاملCOX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma
Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such as rofecoxib, induce bronchoconstriction and asthma in sensitive individuals. This anomaly has not yet been explained. Here, we have used tissue fr...
متن کاملSafety of a cyclooxygenase-2 inhibitor in patients with aspirin-sensitive asthma.
BACKGROUND In 5 to 10% of adult patients with asthma, aspirin (acetylsalicylic acid [ASA]) and most other nonsteroidal anti-inflammatory drugs (NSAIDs) precipitate acute asthmatic attacks. Therefore, choosing an alternative anti-inflammatory agent for patients with adverse reactions to an NSAID is a common problem in clinical practice. The discoveries that cyclooxygenase (COX)-2 is an inducible...
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ورودعنوان ژورنال:
- Chest
دوره 123 6 شماره
صفحات -
تاریخ انتشار 2003